BDBM38034 3-(3-(naphthalen-1-yloxy)propyl)-6-phenylbenzo[b]thiophene-2-carboxylic acid::US10093640, Example 13::US10844032, Example 13

SMILES OC(=O)c1sc2cc(ccc2c1CCCOc1cccc2ccccc12)-c1ccccc1

InChI Key InChIKey=JKKFKPJIXZFSSB-CBZIJGRNSA-M

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 38034   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [172-327](Homo sapiens (Human))
Vanderbilt University

US Patent
LigandPNGBDBM38034(3-(3-(naphthalen-1-yloxy)propyl)-6-phenylbenzo[b]t...)
Affinity DataKi:  5.50E+3nMAssay Description:The assay was run using a fluorescein isothiocyanate-labeled BH3 peptide derived from Bak (FITC-AHx-GQVGRQLAIIGDDINR-NH2) that was purchased from Gen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM38034(3-(3-(naphthalen-1-yloxy)propyl)-6-phenylbenzo[b]t...)
Affinity DataIC50:  5.50E+3nMpH: 7.5 T: 2°CAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In DepthDetails US Patent